EFFECT ON MAN OF PARENTERAL ADMINISTRATION OF A PRODUCTION-LINE MIXTURE OF ISOMERS 2 AND 4, EA 2233

Abstract

A production-line mixture of Isomers 2 and 4 of EA 2233 was administered intravenously to 38 medical volunteers. Nineteen men experienced orthostatic hypotension. Probit analysis by the method of Bliss indicated that the MED50 for orthostatic hypotension was 1.8 micrograms/kilogram. Vasoxyl (methoxamine) and Neosynephrine (phenylephrine) were used to treat the orthostatic hypotension and found to be effective.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1965
Accession Number
AD0369811

Entities

People

  • Harvey W. Neitlich
  • John E. Pless

Organizations

  • Edgewood Chemical Biological Center

Tags

DTIC Thesaurus Topics

  • Air Force
  • Blood
  • Blood Cells
  • Body Weight
  • Cardiovascular Physiological Phenomena
  • Cell Count
  • Chemical Warfare Agents
  • Confidence Limits
  • Data Science
  • Factor Analysis
  • Health Services
  • Hypotension
  • Leukocytes
  • National Security
  • Production
  • Vascular Diseases
  • Volunteers

Readers

  • Graph Algorithms and Convex Optimization.
  • Toxicology/Environmental Toxicology
  • Trauma or Military Medicine