DIFFERENTIAL EFFECTS OF SPECIFIC ANTISERA ON THE REJECTION OF ALLOGENIC AND XENOGENIC SKIN GRAFTS BY SUBLETHALLY X-IRRADIATED MICE
Abstract
Tvelve to fourteen week old female LAF1 mice, non-sensitized or pre-sensitized with two consecutive BALB/c or rat skin grafts, received 670 rad whole body X radiation and orthotopic tail grafts of LAF1, BALB/c, C3D/2 and rat skin. Certain groups of lice received specific antisera intraperitoneally, produced in response to BALB/c or rat spleen cells or to two consecutive BALB/c or rat skin grafts. The data indicate that the first-set response to an allogenic skin graft can be significantly inhibited, in sublethally irrsdiated mice, by specific antisera, while the first-set response to a xenogenic skin graft remains resistant to similar treatient. Specific antisera had no effect upon a pre-existing second-set response. The significance of these data is discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 04, 1963
- Accession Number
- AD0401541
Entities
People
- Leonard J. Cole
- M. L. Tyan
Organizations
- Naval Radiological Defense Laboratory