DIFFERENTIAL RESPONSE TO ALLOGENIC AND XENOGENIC SKIN GRAFTS BY SUBLETHALLY IRRADIATED (670 RAD) AND NON-IRRADIATED MICE SENSITIZED BY VARIOUS MEANS
Abstract
Twelve to 14 week old female LAF1 mice were pre-sensitized either with 3 i.p. injections of BALB/c or rat spleen or skin cells, by means of two consecutive BALB/c or rat skin tail grafts. One week following the last injection or the rejection of the second, skin graft, the mice either were grafted with LAF1, BALB/c, C3D/2 and rat skin or they received 670 red whole body X radiation and were grafted immediately thereafter. The data indicate that skin grafts induce a are vigorous and are radioresistant "second-set" response than do dissociated cells. Pro-sensitization with allogenic spleen cells resulted in prolonged survival of subsequent allogenic skin grafts in sublethally irradiated mice. The second-set response to a xenogenic skin graft was found to be more radioresistant than was that to an allogenic graft. The converse was true with regard to the first-set response.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 11, 1963
- Accession Number
- AD0402294
Entities
People
- Leonard J. Cole
- M. L. Tyan
Organizations
- Naval Radiological Defense Laboratory