INFLUENCE OF THE NORMAL FLORA ON MUCOSAL MORPHOLOGY AND CELLULAR RENEWAL IN THE ILEUM. A COMPARISON OF GERM-FREE AND CONVENTIONAL MICE

Abstract

By comparison of germ-free and conventional mice, many of the morphologic characteristics of the ideal mucosa ordinarily recognized as 'normal' were demonstrated actually to develop in response to the presence of the bacterial flora of the natural environment. Auto radiographic study of the ileum at various times after administration of tritiated thymidine to the two groups of mice revealed that cellular renewal rates in the mucosa are likewise sharply influenced by the normal microbial flora. The rate of turnover of the ileal epithelium in the germ-free state was found to be significantly lower than in the presence of the conventional flora. Although not measured as precisely, turnover of cells in the lamina propria and Peyer's patches appeared to be affected similarly by the living flora.

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Document Details

Document Type
Technical Report
Publication Date
Dec 04, 1962
Accession Number
AD0403101

Entities

People

  • Gerald D. Abrams
  • Heinz Bauer
  • Helmunz Sprinz

Organizations

  • Mount Sinai Hospital

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Buildings And Structures
  • Corporations
  • Environment
  • Epithelium
  • Inventions
  • Materials
  • Mucous Membrane
  • Research Facilities
  • Specifications
  • Thymidines
  • Tissues

Readers

  • Immunology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology