STUDIES ON IMMUNOLOGICAL DIAGNOSIS AND THERAPY OF PARAGONIMIASIS
Abstract
Immunological diagnosis as a screening method for paragonimiasis was made; 115,866 individuals were examined intradermal test with V.B.S. Antigen in Japan during 1954 - 1961. Stool examinations and complement-fixation tests were per formed on positive and doubtful skin reactors. Paragonimus eggs were found in the stools of positive skin reactors, but not in those of negative reactors. It was found that the intradermal test was specific for paragonimiasis. Positive skin reactors were included of present and past infections, and were not always shown the present status of lung fluke infections. Chemotherapy of paragonimiasis with Bithionol, in which studies on the minimum effective dose of Bithionol and changes of abnormal shadows in chest X-ray examinations after treatment with Bithionol, were made. Eighty cases of paragonimiasis were treated with daily dose 20mg/kg - 50mg/kg of Bitin (Bithionol) every other day for 5 - 15 times and completed the follow-up observations for 1 year after the treatments. Seventy-eight out of 80 cases were cured completely. Among 129 abnormal shadows found in 78 cases befortment, 20.9% of them were absorbed immediately after completion of treatment and most of them were absorbed during the period from 1 - 3 months after treatment. The minimum effective dose of Bitin was daily dose 30mg/kg every other day for 10 times and the chest X-ray examinations after the treatments have practical values.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 28, 1963
- Accession Number
- AD0403110
Entities
People
- Muneo Yokogawa
Organizations
- Chiba University