MUTUALLY TOLERANT HOST AND DONOR TYPE IMMUNOLOGICALLY COMPETENT CELLS IN MOUSE RADIATION CHIMERAS
Abstract
Host type immunologically competent cells were found in 4 out of 15 LAF1 (host)-C3H (donor) long-lived radiation mouse chimeras. Three of these 4 chimeras also had donor type lymphoid cells. Therefore, the host and donor immunocompetent cells must have co-existed in a state of mutual homograft tolerance. Of the remaining 11 chimeras tested, 6 did not exhibit host type immunocompetent cells, while 5 showed questionable host-derived immunological activity. Donor immunocompetent cells were detected in a total of 4 of the 15 LAF1-C3H chimeras. Host type (i.e., strain A) immunocompetent cells were detected also in two A-LAF1 radiation chimeras. On the other hand, 10 C3HD2F1 radiation chimeras apparently did not contain host-derived immunogenic cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 19, 1963
- Accession Number
- AD0403271
Entities
People
- Leonard J. Cole
- M. L. Tyan
- W. E. Davis Jr.
Organizations
- Naval Radiological Defense Laboratory