HISTOPATHOLOGY OF GERMFREE ANIMALS.
Abstract
The lymphatic tissue of animals reared in the total absence of a microbial flora was deficient in immunologically competent cells and in humoral factors such as antibody and gamma globulin. These animals showed morphologic and humoral responses which were qualitatively indistinguish able from those of experienced conventional animals. The uptake of bacterial antigen and the antibody response to such antigen was essentially the same in germ free and conventional animals. The response of the lymphatic system to toxic liver injury appeared to be similar in germ free and conventional animals. The local response to trauma, although quantitatively different, was qualitatively the same in germ free and conventional animals, and the response of the lymphatic tissue to irradiation was identical in germ free and conventional animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 30, 1963
- Accession Number
- AD0403868
Entities
People
- Fiorenzo Paronetto
- Hans Popper
- Heinz Bauer
- Richard E. Horowitz
Organizations
- Mount Sinai Hospital