MEASUREMENT OF ADP:O VALUES IN RAT LIVER HOMOGENATES. II. EFFECTS OF PURINE AND PYRIMIDINE NUCLEOTIDES ON RESPIRATION AND PHOSPHORYLATION

Abstract

The effects of a number of nucleotides on respiration and phosphorylation were studied. In all cases where phosphorylation was stimulated, respiration increased correspondingly. Studies with C14-labeled nucleotides gave no indication that non-phosphorylative side reactions interfere with ADP:O measurements. These findings provide additional evidence that ADP:O values are a reliable measure of oxidative phosphorylation in liver homogenates from normal rats.

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Document Details

Document Type
Technical Report
Publication Date
May 20, 1963
Accession Number
AD0406946

Entities

People

  • E. H. Strickland

Organizations

  • United States Army Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Biochemistry
  • Biological Sciences
  • Biomedical Research
  • Chemical Synthesis
  • Chemistry
  • Enzymes
  • Metabolism
  • Mitochondria
  • Nucleotides
  • Organic Chemistry
  • Physical Chemistry
  • Propionic Acid
  • Respiration
  • Side Reactions
  • Skeletal Muscle
  • United States

Fields of Study

  • Biology
  • Chemistry

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry