THE ANTIDIURETIC PROPERTIES OF CHLOROTHIAZIDE IN DIABETES INSIPIDUS DOGS. 2. POSSIBLE ROLE OF THE ADRENAL GLAND

Abstract

The possible role of the mineralocorticoids in the antidiuretic response to chlorothiazide therapy was investigated in diabetes insipidus and adrenalectomized dogs. Administration of sodium retaining steroids to diabetes insipidus dogs did not reproduce the urinary changes associated with chlorothazide therapy. In addition, the antidiuretic response to chlorothiazide was not altered by adrenalectomy or spironolactone ad ministration. Therefore, the presence of the sodium-retaining steroids are not essential for the antidiuretic response of chlorothiazide in diabetes insipidus.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1963
Accession Number
AD0406947

Entities

People

  • Jay Y. Gillenwater

Organizations

  • United States Army Medical Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adrenal Glands
  • Animals
  • Biological Sciences
  • Biomedical Research
  • Body Fluids
  • Chemistry
  • Endocrine Surgical Procedures
  • Excretion
  • Glands
  • Government Procurement
  • Health Services
  • Hormones
  • Infusions
  • Laboratory Animals
  • Physiology
  • United States
  • Urine

Fields of Study

  • Medicine

Readers

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