METABOLISM OF FATTY ACIDS AND RELATED SUBSTANCES IN ANIMALS EXPOSED TO COLD

Abstract

In 1961 evidence was presented for the fact that the microsomes of the liver from animals fasting at 25 degrees C or 0 degrees to 2 degrees C are inhibitory to the lipogenic activity of the liver cell. It was further shown that sonic treatment of these microsomes liberated, in a water soluble form, an inhibitory material which mimicked that of the microsomes from these cells. Chromatography of Sephadex G25 indicated that this inhibitory material was of a colloidal nature. For this reason it was decided to investigate further the colloidal nature of this substance by the process of dialysis. It can be seen that this microsomal inhibitor of lipogenesis is non-dialyzable and presumably, therefore, is either a colloid or a substance tightly bound to a colloid.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1961
Accession Number
AD0407017

Entities

People

  • David Rapport

Tags

DTIC Thesaurus Topics

  • Adipose Tissue
  • Cells
  • Chromatography
  • Column Chromatography
  • Connective Tissue
  • Dietary Fats
  • Enzyme Inhibitors
  • Fatty Acids
  • Gel Electrophoresis
  • Government Procurement
  • Incubation
  • Inhibition
  • Inhibitors
  • Materials
  • Metabolism
  • Plastic Explosives
  • Tissues

Fields of Study

  • Biology

Readers

  • Analytical Chemistry
  • Prostate Cancer Biology.
  • Toxicology/Environmental Toxicology