EFFECTS OF ANTI- AND PSEUDO-PARKINSON DRUGS ON SHIVERING
Abstract
Effects of atropine, an anti-Parkinson agent, and reserpine, a pseudo-Parkinson agent, on the intensity of shivering in cats were determined. This intensity was measured by the ratio of shivering oxygen consumption rate (VO2) to resting VO2. At a dose level (5 mg/kg I.P.) in excess of that necessary to suppress Parkinson or experimentally-induced alternating tremor, atropine sulphate had no effect on the intensity of cold-induced shivering. At a dose level of 0.5 mg/kg I.V., reserpine suppressed shivering but evoked an alternating tremor with Parkinson characteristics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1962
- Accession Number
- AD0407097
Entities
People
- A. Hemingway
- D. G. Stuart
- R. George
- W. J. Freeman
- W. M. Price
Organizations
- University of Southern California