PROSPECTIVE ANTIRADIATION AGENTS

Abstract

The extension of the five-step synthesis of 3-amino-2-methyl-2- butanethiol hydrochloride was described. An investigation of possible reaction of acetylene with 1-carbethoxy-3-pyrrolidone was pursued with the hope of forming an intermediate acetylenic carbinol which would ultimately lead to an aminothiol wherein the amino group would be part of the heterocyclic five- membered ring. The possibilities of forming aminothiols from aminoalkenes formed from Schiff bases was also investigated, but unfortunately, these intermediates failed to react with thiols to produce the described sulfide. The synthesis of aminoalkane thiols was also described.

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Document Details

Document Type
Technical Report
Publication Date
Mar 31, 1963
Accession Number
AD0407579

Entities

People

  • Gardner W. Stacy

Organizations

  • Washington State University

Tags

DTIC Thesaurus Topics

  • Acetic Acid
  • Acetylenes
  • Alcohols
  • Alkynes
  • Aluminum
  • Aluminum Hydride
  • Amines
  • Carbinols
  • Chlorides
  • Cyclohexanones
  • Governments
  • Hydrides
  • Hydrogen
  • Imines
  • Ketones
  • Nitrogen Compounds
  • Radioprotective Agents

Fields of Study

  • Chemistry

Readers

  • Clinical Trial Research.
  • Organic Chemistry