EFFECTS OF ANTITOXIDANTS ON RESISTANCE TO RADIATION INJURY
Abstract
Since BHT (butylated hydroxy toluene) and certain other antioxidants significantly prolonged the average survival time of mice exposed to multiple sublethal doses of total body x-irradiation, experiments were undertaken to determine the effects of antioxidants of diverse structure and activity and antioxidant synergists on length of survival following continuous exposure to a lethal dose of total body gamma radiation in the rat. BHT when fed at a 0.5% level in a purdiet and ascorbic acid at a 0.1% level significantly increased the average survival time of irradiated rats over that of rats fed the unsupplemented purified diet. Polygard (tri(nonylated phenyl) phosphites) when fed at levels of 0.25% and 0.5% and citric acid and phosphoric acid at levels of 0.1% in the purified diet also appeared to have some activity in this regard. Other antioxidants tested had little if any protective effect. The average survival time of irradiated rats was significantly longer for rats fed a natural food stock ration than for those fed the basal purified diet. No cor relation was observed between the weight incre ment, organ weights or microscopic appearance of the tissues of irradiated rats with length of survival on any of the diets employed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1963
- Accession Number
- AD0410008
Entities
People
- B. H. Ershoff
- G. S. Bajwa