On the Effect Of Neurohypophysial Hormone on Thyroid Activity
Abstract
Experiments were carried out to elucidate the role of vasoprressin in the thyrotropin discharge and thyroid secretion, measuring thyroidal 131I uptake (T/S), plasma PB131I level, as well as histologi cal examination of the thyroid gland, in rats. Though a single dose of Pitressin failed to change the T/S in rats kept at 20 degrees centigrade, successive administrations of Pitressin tannate resulted in a suppression of the rise of T/S due to chronic cold exposThese results well coincided with that in the histological exami nation. Pitressin, but not synthetic lysine vasopressin, suppressed the PB131I level which was slightly elevated by minor surgical stress used. Pitressin and lysine vasopressin demon strated suppressive effect in the same extent, if these preparations were given intraperitoneally. The rise of plasma PB131I level following exoge nous thyrotropin was not affected by these neurohypophysial preparations. The administration of Pitressin in various doses and routes did never increase the plasma PB131I level in the rats under experimental conditions employed.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 14, 1963
- Accession Number
- AD0410075
Entities
People
- Shinji Itoh
Organizations
- Hokkaido University