METABOLIC DISORDERS AND THERAPEUTIC APPROACHES TO RENAL FAILURE
Abstract
A model system for determining skin histocompati bility in man has been described, based upon the acceleration of grafts on an indifferent recipient immunized previously by one member of the donor-recipient pair to be tested. An alpha-1 glyco-protein isolated from the serum and concentrated in thymic tissue prolonged the life of 30% of homologous skin grafts in rats for 6 months. Utilizing immunosuppressive therapy in the form of Umuran, Actinomycin-C, Azaserinecortisone, prolonged tolerance for a human renal homograft from a nontwin donor in 5 recipients was produced. In one of these a kideny transplanted from a cadaver has functioned well enough to sustain active life for 15 months. An inlying plastic conduit for the performance of long-term, chronic peritoneal irrigation is described and has been utilized by two patients performing peritoneal dialysis at home for a period of 9 months. Homograft antigens on canine platelets have been isolated in soluble form. Homograft antibody elicited from rejected canine kidneys in a soluble fluid phase will react with this antigen in the classic immune reaction of agglutination complement fixation and immune adherence.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1963
- Accession Number
- AD0410301
Entities
People
- John P. Merrill