METABOLIC EFFECTS OF BLOOD TRANSFUSION.
Abstract
Hemodynamic studis were made of the hemodynamic effects of graded constant intravenous infusions of KC1 in the dog, with recordings of cardiac output, right and left ventricle, central venous, femoral artery and intratracheal pressures, to gether with right and left ventricular myocardial contractility, electrocardiogram, and ballisto cardiograph. In intact animals there is an in crease in blood pressure, occasionally marked, an increase in total peripheral resistance and mean transit time, and essentially no change in cardiac output or myocardial contractility. The ballis tocardiograph shows a relative preponderance of the H wave over the J wave, and an increase in the respiratory variation of the H, I, and J waves. The animals died in ventricular fibril lation of serum potassium levels of approximately 10 mEq/L. In these animals KC1 infusion led to a variable response in blood pressure, a decrease in cardiac output and myocardial contractility, increase in total peripheral resistance, and a steady increase in mean transit time. These animals invariably died in asystole when serum potassium was elevated to 15 mEq/L or above. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1963
- Accession Number
- AD0410375
Entities
People
- John P. Bunker
Organizations
- Stanford University Medical Center