RIFT VALLEY FEVER VIRUS HEPATITIS LIGHT AND ELECTRON MICROSCOPIC STUDIES IN THE MOUSE

Abstract

Rift Valley fever virus produces a necrotizing hepatitis in mice that is similar to certain other virus hepatitides. The virus infects the hepatic parenchymal cells and new virus is formed in the cytoplasm within a membrane- limited system resembling the Golgi apparatus. Unique structural alterations of the ergastoplasm are associated with this process and may be manifestations of metabolic dysfunction. The acidophilic nuclear inclusion is not formed of virus matrix or virus particles and may represent a degenerative phenomenon. Changes in the Kupffer cells follow infection of the parenchymal cells.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1963
Accession Number
AD0410394

Entities

People

  • Bernard Carlyle Easterday
  • Malcolm H. Mcgavran

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Acids
  • Arbovirus Infections
  • Arteries
  • Blood
  • Cells
  • Cellular Structures
  • Deoxyribonucleic Acids
  • Electron Microscopes
  • Electron Microscopy
  • Golgi Apparatus
  • Macrophages
  • Microscopes
  • Organelles
  • Rift Valley Fever
  • Rift Valleys
  • Viruses
  • Yellow Fever

Readers

  • Immunology
  • Molecular and Cellular Biochemistry
  • Molecular and Cellular Biology

Technology Areas

  • Microelectronics