ELECTROPHORETIC PATTERNS OF PLASMA FROM VACCINATED MONKEYS FOLLOWING RADIATION AND TULAREMIC INFECTION
Abstract
The usefulness of plasma electrophoretic patterns as one of the major markers of the physical condi tion of the Macaca mulatta was demonstrated in studies with monkeys vaccinated with the live tularemia vaccine and irradiated 24 hours after respiratory challenge with Pasteurella tularensis SCHU S4. The analysis of the extent of infection as well as differentiation between the treated groups was based on clinical signs, mortality rate, and hematological, serological, bacterio logical, and pathological studies. The vaccinated challenged-irradiated group (VCX) in their re sponses more nearly resembled the challenged group (C) than the vaccinated-challenged group (VC). The VC group, with milder disease symptomatology, showed a less marked drop in albumin than in the C or VCX groups. In addition, the return toward normal values was most rapid in the VC group and least rapid in the C group. Changes in the alpha 1 peak were less marked, with only an occasionalincrease in the VCX group. The alpha 2 peak of the VCX group increased signifi cantly and remained high longer than the alpha 2 peaks of the other groups. The beta peak rose in both vaccinated groups, VC and VCX, but remained constant at a normal level in the C group. In contrast, however, the gamma globulin response was markedly increased in the C group.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1963
- Accession Number
- AD0410478
Entities
People
- John E. Nutter
- Maurice L. Gu
Organizations
- United States Army Biological Warfare Laboratories