CYTOCHEMISTRY OF BLOOD GLYCOGEN IN MAMMALS AFTER SINGLE WHOLE-BODY X- IRRADIATION,
Abstract
Single whole-body x-irradiation of rate with 800 r results after 10- 30 minutes in a loss of glycogen by the neutrophils and thrombocytes. The decrease in glycogen content is at a maxi mum 1-3 hours after exposure against a back ground of marked leukocytosis and neutrophilosis. Unlike temporary variations in the normal poly saccharide level, disintegration once begun is uncontrollable. Disintegration of the poly saccharide progresses from the central, cir cumnuclear zones to the periphery of the cells. Six hours after irradiation the peripheral blood is found to contain many destroyed neutro phils with only traces of glycogen. After 24 hours there is a pronounced leukopenia, despite the development of new generations of cells with moderately high glycogen content approximating the normal. Cytochemical impairment of glycogen metabolism caused by irradiation precedes morphologically apparent injury to neutrophil nuclei and cytoplasm. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 28, 1963
- Accession Number
- AD0410618
Entities
People
- A.l. Shabadash
- Yu.b. Kheifets
Organizations
- Joint Publications Research Service