EFFECTS OF DECABORANE ON BRAIN ACTIVITY

Abstract

The effects on intraperitoneal injection of decaborane have been investigated in monkeys with electrodes permanently implanted in the brain. One single injection of 5 mg/kg produced a marked behavioral depression, with only moderate electroencephalographic modifications, followed by death in 18 hours. Four daily doses of 3 mg/kg produced depression, somnolence, twitching in both arms, accompanied by bursts of high-voltage activity, localized in the internal capsule. Death occurred 3 days later. Daily doses of 1 mg/kg up to a total of 14 mg/kg pro produced depression, muscular twitching, anorexia, and a typical electroencephalographic pattern, but the animals recovered completely. Depression may be related to reticular system involvement. Motor symptomatology could depend on disturbances of heavily myelinated motor axons which may have a special affinity for the liposoluble decaborane. Hypothalamic involvement was questionable, but neighboring structures, especially the internal capsule showed electrical disturbances.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 1963
Accession Number
AD0411769

Entities

People

  • Jose M. Delgado

Organizations

  • Yale University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Biomedical Research
  • Brain
  • Central Nervous System
  • Electrodes
  • Health Services
  • High Voltage
  • Hypothalamus
  • Materials
  • Medical Personnel
  • Nervous System
  • Public Health
  • Seizures
  • Thalamus

Fields of Study

  • Psychology

Readers

  • Neuroscience
  • Toxicology/Environmental Toxicology