EXPERIMENTAL AND CLINICAL INVESTIGATIONS IN THE MANAGEMENT OF TRAUMA AND SHOCK.
Abstract
Investigations have been carried out to deter mine ideal methods of managing cardiovascular trauma, particularly penetrating wounds of the carotid arteries, arteriovenous fistulas, and vascular injuries associated with musculoskeletal trauma. Additional studies were performed evaluating and attempting to improve methods of managing penetrating wounds of the neck, trauma tic injuries of the liver, and injuries of the colon. Studies in regard to changes inary blood flow and cardiac output in the presence of hemorrhagic shock were completed. Animal investigations were instituted in order to de termine the ideal arterial replacement graft for use in the presence of infection or anticipated infection associated with massive soft tissue damage. Grafts of knitted, crimped polypropylene appear to be well tolerated in infected areas; however, tissue fixation of these grafts is poor and long term evaluation demonstrates them to be inadequate as arterial replacement grafts. Investigations were also instituted in order to evaluate the use of autogenous veins as arterial replacement grafts under similar cirucmstances. One problem related to this appears to be whether or not autogenous veins maintain viabil ity when used as arterial replacement grafts. The metabolic rate of such grafts was found to be insufficient for determination by Warburg technic; therefore, attempts will be made to determine this fact by use of the Polarograph. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1963
- Accession Number
- AD0412828
Entities
People
- Arthur C. Beall
- Michael E. Debakey
- O.brewster Harrington
Organizations
- Baylor University