CHEMICAL FACTORS IN THE EXCITATION OF CEREBRAL TISSUES.
Abstract
Mammalian cerebral tissues, electrically stimu lated during incubation in isolation, showed a number of coordinated metabolic and electrical changes. Their respiratory rates increased in fashions which were quantitatively related to the duration, frequency, and potential of the stimulating pulses applied. Corresponding in crease in movements of Na and K took place. Under limiting conditions these were of 5 to 6 micron equiv./g. tissue/applied pulse, and in active ion movement implied ratios of Na extruded:O utilized of 1.7, values which were compared with those derived in nonmammalian systems. Membrane po tentials in cellular elements of the tissue diminished on stimulation and subsequently re covered; the time-course of diminution and re covery was directly connected with the concomi tant ion movement. Chlorpromazine, phenobarbi tone and cocaine in concentrations involved in their actionsugs, and also clupeine, af fected both ion movements and membrane potentials of the stimulated tissue. They did so in fashions which were characteristic of the added substance. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1963
- Accession Number
- AD0413762
Entities
People
- Henry Mcilwain
Organizations
- University of London