EFFECT OF DRUGS ON CENTRAL NERVOUS SYSTEM NEURONES.

Abstract

The present report exposes the results obtained during an investigation on the effects of drugs on the electrical activity of single cortical neurones. During the couse of this investigation the following drugs were injected: eserine, scopolamine, amphetamine, tryptamine and lysergic acid diethylamide (LSD). Although it is not possible with the present limited data to arrive at any clear-cut conclusion, some com ments and indications in regard to future development of the research are the following: (1) In the sensorimotor cortex there seems to be some layers that have many cells responding with increased firing rate after application of external stimuli; (2) Both eserine and amphe tamine provoke an increase in firing of single neurones; and (3) The ''flattening of the EEG tracing provoked by tryptamine and LSD seems to be relat 1t least where it is concerned with the limbic cortex, with a diminution of cellular activity. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1963
Accession Number
AD0414045

Entities

People

  • Vincenzo G. Longo

Organizations

  • Istituto Superiore di Sanità

Tags

DTIC Thesaurus Topics

  • Acids
  • Central Nervous System
  • Chemically-Induced Disorders
  • Diseases And Disorders
  • Drug Abuse
  • Firing Rate
  • Lysergic Acids
  • Mental Disorders
  • Nervous System
  • Social Problems
  • Social Sciences
  • Sociology
  • Substance-Related Disorders

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Neuroscience
  • Theoretical Analysis.