A STUDY OF SERUM HEPATITIS FROM STORED PLASMA
Abstract
A prospective controlled study of the frequency of hepatitis following the transfusion of pooled human plasma stored for six months in the liquid state at 30 - 32 Centigrade has been initiated. Surgical Service patients who receive only plasma and no other human blood products are the subjects of the study. The control solution, administered in a double-blind fashion, is five per cent human albumin solution. All patients allocated to the program are being followed in an identical manner, with clinical examinations and liver function studies at monthly intervals for a total of 180 days. Forth-seven patients were allocated to the follow-up study program from February 1 to August 1, 1963. Two patients have completed 180 days of study without evidence of hepatitis. No evidence of hepatitis has been present to date in the other patients under study, except for one subject. This patient developed a mild, anicteric lesion with slight serum transaminase elevations, from which he has recovered. Liver biopsy revealed mild focal changes consistent with mild anicteric hepatitis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1963
- Accession Number
- AD0414660
Entities
People
- Allan G. Redeker
Organizations
- University of Southern California