THERMAL INJURY OF THE SKIN
Abstract
''Toxins'' were demonstrated in the blood of acutely burned or injured human subjects as determined by the cytotoxic effect on Hela cells, the cytolytic effect on red cells of acutely burned or injured individuals, and precipitinogens against healed burn sera. ''Antitoxicantibody''-like substances were demonstrated in the sera of healed burned individuals by their neutralization of the cytotoxic effect on Hela cells and the presence of ''hemolysins'' and precipitins. In preliminary clinical trials it was found that the administration of blood or plasma from healed burned donors to critically toxic burned or injured subjects was associated with a precipitous change in their clinical condition which was manifested by increasing awareness, appetite, and spontaneous mobility, and a decrease in local edema, pain, irritability, and restlessness. The post-transfusion sera of such critically ill subjects lost their tissue culture toxicity which corresponded with the clinical improvement.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1960
- Accession Number
- AD0414781
Entities
People
- Alan B. Goodman
- Donald Findlay
- Frank Higgins
- Graham P. Lewis
- Sol R. Rosenthal
- Wilma A. Spurrier
Organizations
- University of Illinois Urbana–Champaign