NEUROHUMORAL CONTROL OF THYROTROPIC ACTIVITY.
Abstract
This study was aimed at analyzing the changes in ACTH and TSH secretion, induced by such factors as stress, thyroidectomy, adrenalectomy, thyroid hormone administration or associations thereof, in terms of altered rates of synthesis, release or disappearance of these hormones, by concurrently assessing, as a function of time following onset of the stimulus, their concentrations in the pituitary and in the blood, and by determining their rates of disappearance from the circulation, following exogenous administration. It was found that: (1) Stress, as exemplified by surgical trauma or faradic stimulation, in addition to stimulating ACTH secretion, simultaneously depresses the synthesis and release of TSH, but has no effect on the removal rate of circulating TSH. (2) Prior adrenalectomy does not influence the TSH response to stress which is therefore not mediated by corticosteroids, or by catecholamines of medullary origin. (3) Thyroidectomy slows down the disappearance rate of circulating TSH, in addition to stimulating TSH secretion. (4) Adrenalectomy depresses both the rate of secretion of TSH and its rate of removal from the circulation. (5) Small and larger doses of triiodothyronine respectively enhance the synthesis and block the release of TSH in the thyroidectomized animal. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 31, 1963
- Accession Number
- AD0414858
Entities
People
- Claude Fortier
Organizations
- Laval University