COMPARISON OF SEROLOGIC REACTIONS IN EXPERIMENTAL CANINE AND SIMIAN COCCIDIOIDOMYCOSIS
Abstract
Three groups of monkeys and three groups of dogs were each exposed by the respiratory route to graded doses of approximately 9500, 2500, and 325 dry arthrospores of Coccidioides immitis strain Silveira. Blood for serological tests was drawn from these animals prior to exposure and at 2, 5, 9, 14, 17, and 20 weeks postexpo sure. Precipitins were detected using agar gel. Sera for c.f. antibodies was pretreated with complement before testing. Infections in monkeys ranged from lethal to severe, whereas infections produced in dogs were severe to mild. All monkeys in the high-dose group died of pulmonary coccidioidomycosis between Days 11 and 61 post exposure. No dogs died from the disease. In sera from infected dogs, the highest median precipitin titers occurred at five and nine weeks postexposure. Titers fell after these times in all dose groups. Precipitin titers in the medium and low-dose groups of monkeys reached their highest median values at 14 weeks postexposure and then declined slightly. Precipitin titers in infected monkeys were consistently higher than those in infected dogs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1963
- Accession Number
- AD0416146
Entities
People
- Edwin Palmer Lowe
- James Thomas Sinski
- John Emil Del
- Louis Francis Maier
- Merida William Castleberry
Organizations
- United States Army Biological Warfare Laboratories