OBSERVATIONS ON ENERGY METABOLISM IN IRREVERSIBLE HEMORRHAGIC SHOCK.
Abstract
Two unusual mitochondria were isolated from dogs subjected to prolonged oligemic hypotension: one from the liver appears to represent an adaptation to the abnormal physiological conditions imposed by the prolonged hypotension, the other, from the heart, seems to have sustained a permanent defect at the site concerned with ATP-synthesis. However, despite the presence of these abnormal mitochondria in the myocardium we have not yet succeeded in obtaining convincing evidence of any functional impairment of the heart as a whole. In both the dog and the rat the initial hemorrhage gives rise to a hyperglycemia, partly under adrenalin control. A peak concentration is reached at about the time of first reinfusion, after which a profound hypoglycemia is established which persists until death. In the rat survival appears somehow related to the maintenance of a hyperglycemic state. Despite persistantly elevated catecholamine levels in the circulating blood of our experimental dogs, the hearts at the time of death are severely depleted of norepinephrine. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 07, 1963
- Accession Number
- AD0416333
Entities
People
- Charles W. Crumpton
- Helen Hift
Organizations
- University of Wisconsin–Madison