STUDIES OF ADAPTATION OF PROTEIN MALNUTRITION.
Abstract
The rationale and technique of producing a static preparation of chronic protein malnutrition in rats and dogs is reported. The technique employs a period of fasting adjusted to initial weight of the animal and then ''titration'' to a low protein intake adequate in calories to maintain weight at 70-80% of initial weight. Such animals have been observed for over six months. They are normally active and appear well. Studies of such protein deficient animals include: (1) Liver and intenstine mass strikingly reduced while bone growth progresses; (2) Calcium is abosrbed more avidly and labile calcium pool is turned over more rapidly; (3) Qualitative and quantitative changes occur in serum proteins with loss of alpha and beta globulins and relative increase in gamma globulins; and (4) Granuloma formation is inhibited. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 30, 1963
- Accession Number
- AD0417590
Entities
People
- Milton E. Rubini
Organizations
- University of California, Los Angeles