DEVELOPMENT OF TISSUE HYPOXIA DURING PROGRESSIVE HYPERTHERMIA,
Abstract
Heart rate, mean arterial pressure, respiratory rate, minute volume, arterial blood PO2, PCO2, pH, hemoglobin saturation, lactic acid, and pyruvic acid were determined on anesthetized dogs during progressive hyperthermia. Heart rate increased as rectal temperature (Tr) in creased. Mean arterial pressure began to decline at Tr between 41 and 42 C. Respiratory rate and minute volume reached maximum values at tempera tures around 42 C. Arterial PO2 and hemoglobin saturation did not decrease until rectal tempera ture exceeded 42 C. PCO2 decreased and pH in creased from control values as minute volume increased. Arterial excess lactate showed the most marked rise at Tr's between 41 and 42 C. The conclusion was made that failure of external respiration is not the primary physiologic failure during progressive hyperthermia but the development of tissue hypoxia may be. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1963
- Accession Number
- AD0418284
Entities
People
- H.meyer Frankel
- James P. Ellis
- Stephen M Cain
Organizations
- United States Air Force School of Aerospace Medicine