A STUDY ON THE PHYSIOLOGY OF MECHANICAL TRAUMA.
Abstract
In the hope of increasing the specificity of the radioprotective action of 2-mercaptoethyl amine and of protecting the genetic material of the cell, which is peculiarly sensitive to radiation damage, a group of N-5-pyrimidyl cysteamines, of N-8-purinyl cysteamines, and of related compounds was prepared. The selenium analogs of cysteamine and of aminoethylisothiouronium bromide hydro bromide and of related radioprotective mercaptans were synthesized. In the search for mercaptan and selenomercaptan derivatives stable to oxida tion, but capable of being hydrolyzed within the host to be protected against ionizing radiation, a group of thioacyl and selenoacyl compounds was synthesized and the kinetics of their hydrolysis and aminolysis reactions investigated. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 19, 1963
- Accession Number
- AD0418409
Entities
People
- Henry G. Mautner
Organizations
- Yale University