THE ACUTE MAMMALIAN TOXICITY OF RARE EARTH NIT RATES AND OXIDES
Abstract
Results of acute toxicity studies on rare earth nitrates indicate that their acute toxicity is highly dependent on the route of administration. The nitrate salts were moderately toxic when given intraperitoneally to rats and mice and only slightly toxic when administered orally to rats. With the exception of the transition elements, for which the oral LD50 values were greater than 5,000 mg./kg., the compounds generally exhibited an in crease in toxicity with increasing atomic weight. The light lanthanons are highly toxic to rats by the intravenous route. The nitrate salts of cerium, praseodymium, neodymium, and samarium were from 7 to 11 times more toxic to females than to male rats. Erbium nitrate, a heavy lanthanon, did not show the marked sex difference in toxicity to rats. Rats were able to tolerate 1,000 mg./kg. of the rare earth oxides given orally or intraperitoneally.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1963
- Accession Number
- AD0419188
Entities
People
- Bernard E. Hietbrink
- David W. Bruce
- Kenneth P. Dubois