THE INTERACTION OF ALDOSTERONE AND OTHER STEROIDS WITH LIVER AND KIDNEY CELL MEMBRANES AND WITH SUB CELLULAR FRACTIONS OF THE KIDNEY,

Abstract

This report represents an investigation of the interaction of aldosterone with kidney and liver cell membranes and with kidney subcellular frac tions and to compare this interaction with that of other steroid hormones. Aldosterone is weakly bound to kidney subcellular fractions. Liver and kidney cell membranes were found to either take up the steroids tested according to their solu bility in lipids or to bind them in accordance with the polarity rule of steroid-protein inter action. Spirolactone failed to displace aldo sterone from the kidney cell membranes. The re sults indicate that none of the cell fractions investigated bind aldosterone strongly or preferentially. (Author)

Document Details

Document Type
Technical Report
Publication Date
May 21, 1963
Accession Number
AD0419658

Entities

People

  • E.t. Davidson
  • F. Devenuto
  • U. Westphal

Organizations

  • United States Army Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Aldosterone
  • Anatomy
  • Biological Sciences
  • Cell Membrane
  • Cells
  • Membranes
  • Polarity
  • Subcellular Fractions

Fields of Study

  • Computer science

Readers

  • Molecular and Cellular Biochemistry
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