SOME METABOLIC EFFECTS OF METHIONINE TOXICITY IN THE RAT,
Abstract
Rats consuming a 15% casein diet containing 4.0% of DL methionine developed the following metabolic alterations in the liver: increased activities of arginase, tryptophan pyrrolase, glutamic-oxalacetic and pyruvic transaminase, decreased levels of DPN and slightly increased levels of total and neutral fat. However, the fat content approached a normal level at the end of the tenth week of the experimental period. Urinary excretion of a number of amino acids was also markedly increased. Supplementation of the high methionine diet with 4.0% of glycine decreased the activity of arginase and the levels of some amino acids in the urine. The data indicate that ingestion of excess methionine leads to a disorder in nitrogen metabolism, and that the supplemented glycine diminishes these catabolic processes. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1963
- Accession Number
- AD0419728
Entities
People
- D. A. Vaughan
- G. J. Klain
- Lucile N. Vaughan