THE ANTIDIURETIC PROPERTIES OF CHLOROTHIAZIDE IN DIABETES INSIPIDUS DOGS. I. EFFECT ON SOLUTE, WATER, AND ELECTROLYTE EXCRETION,
Abstract
Chlorothiazide decreased the urine volume and increased the urine concentration in diabetes insipidus dogs. The one consistent altered renal function was a decrease in ''free water'' clearance. There was no change in GFR, RPF, TmPAH, plasma volume extra-cellular fluid, and total body water. No evidence was found for any alteration in thirst or an ADH-like effect. Since mercuhydrin and diazoxide were not antidiuretic and salt blocked the antidiuretic response, it was felt that the antidiuresis is dependent upon the saluretic properties of chlorothiazide. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 15, 1963
- Accession Number
- AD0420322
Entities
People
- Jay Y. Gillenwater
Organizations
- United States Army Medical Research Laboratory