THE PATHOGENESIS OF PLAGUE. 1. A STUDY OF THE CORRELATION BETWEEN VIRULENCE AND RELATIVE PHAGOCYTOSIS RESISTANCE OF SOME STRAINS OF PASTEURELLA PESTIS

Abstract

This report presents evidence that when avirulent strains of P. pestis that produce the capsular antigen Fraction I are grown under conditions that induce a high degree of phagocytosis resistance in typical virulent strains, they also acquire the same degree of resistance. Virulent strains that do not produce detectable amounts of this antigen acquire a much more limited degree of resistance to phagocytosis; in fact, they are not at all resistant to ingestion by guinea pig macrophages. It is suggested that the major factors determing the virulence of P. pestis are not associated with resistance to phagocytosis, but rather, with the intracellular survival and multiplication of the bacilli following phagocytosis.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1963
Accession Number
AD0422364

Entities

People

  • G. M. Fukui
  • M. J. Surgalla
  • W. A. Janssen
  • W. D. Lawton

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Anticoagulants
  • Bacteria
  • Biological Laboratories
  • Blood
  • Cells
  • Gammaproteobacteria
  • Government Procurement
  • Laboratory Animals
  • Leukocytes
  • Macrophages
  • Microorganisms
  • Pathogenesis
  • Pathogenic Bacteria
  • Resistance
  • Rodents
  • United States

Fields of Study

  • Biology

Readers

  • Immunology