PATHOGENESIS OF EXPERIMENTAL TULAREMIA IN MONKEYS: EFFECT OF PARTICLE SIZE
Abstract
The purpose of the experiments described in this report was to determine the primary sites of infection and subsequent histogenesis of lesions in lungs of rhesus monkeys exposed to the SCHU S4 strain of Pasteurella tularensis in aerosols consisting of particles either one or eight microns in diameter. The monkeys were sacrificed at 1/3, 12, 24, 72, and 96 hours after exposure and tissues were examined by conventional pathological techniques and fluorescent antibody methods. Under the conditions of these experiments the respiratory bronchiole was the primary site of infection in the lung of rhesus monkeys. Intracellular P. tularensis was demonstrated in respiratory bronchioles by fluorescent antibody straining of tissues obtained 20 minutes after exposure to aerosols of one-micron particles.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1963
- Accession Number
- AD0422365
Entities
People
- Charles W. Beard
- Edward B. Derrenbacher
- James R. Rooney
- John D. White
- Patricia A. Prickett
Organizations
- United States Army Biological Warfare Laboratories