EFFECTS OF RADIATION COMBINED WITH ANESTHESIA AND TRAUMA.
Abstract
A study of diurnal variation in response to radiation, tourniquet shock, drum trauma, and anesthesia was undertaken. The experiments concluded showed that tourniquet shock was the only insult somewhat modified by the time of exposure. Whereas a 250 rad mid line dose in the dog represented an LD-50 at 30 days without anesthesia or surgical trauma, a dose of 190 rads becomes an LD-80 when anesthesia and/or skin grafting was superimposed upon the radiation. The takes of autologous skin grafts in control animals was 90%. Doses of radiation of 190-200 r had no effect on the number of takes. Animals that were exposed to greaten doses did not survive longer than the 21 days necessary to evaluate a successful graft. Of the parameters thus far investigated, few consistant changes in metabolism have been found that could be associated with irradiation, except for an increase in liver weight following irradiation and starvation; and the appearance of an abnormal component in the blood of irradiated dogs. This has not been identified nor is its significance known. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1963
- Accession Number
- AD0422394
Entities
People
- Howard L. Zauder
Organizations
- Jefferson Einstein Hospital