RESEARCH ON PROCEDURES FOR THE LOW-TEMPERATURE PRESERVATION OF BLOOD. IN VIVO EVALUATION OF PROCESSES FOR THE LOW-TEMPERATURE PRESERVATION OF HUMAN BLOOD BASED ON RAPID COOLING AND WARMING AND PROTECTION BY POLYMERS.
Abstract
Two distinct cryogenic preservation procedures for blood using extracellular polymers have been investigated using autologous transfusions for survival measurement. Processing was conducted in half or one pint quantities and a portion or all of the red cells transfused either directly as thawed, as packed cells or as cells resuspended in autologous plasma. Average survival data were differentiated according to variations in procedures. These results show that the use of albumin in conjunction with PVP as a protective additive has stabilized the survival values of the frozen and thawed erythrocytes and also that the fasting state of the donor can contribute to the survival of these cells. Of primary interest is that cells protected from freeze-thaw damage by extracellular polymers do survive in-vivo to an extent comparable to that observed in blood banked by conventional procedures. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1963
- Accession Number
- AD0423383
Entities
People
- A. P. Rinfret