THE ETIOLOGY AND PROPHYLAXIS OF INFECTIOUS HEPATITIS
Abstract
The incidence of hemagglutinins to monkey erythrocytes was surveyed in over 1,000 sera from normal, Non-IH liver disease and IH disease donors. No significant difference in incidence or titer of warm or cold agglutinins that would distinguish infectious hepatitis from control specimens is confirmed. In a second phase of this study, methods for inactivating the nonspecific agglutinins (NSA) were developed in order to determine if the NSA masked a disease-specific agglutinin. Approximately 35% of acute IH or SH specimens contained a masked agglutinin in contrast to approximate 8% of control specimens. Attempts are in progress to increase the sensitivity of the test to masked agglutinins and to neutralize them. Attempts were made to isolate virus from acute IH serum specimens using cultures from a variety of primary human tissues. In no case was the effect transmissible beyond the fourth passage. During this phase of study, a toxin was observed in fresh serum from approximately 90% of patients with acute liver disease whereas normal controls were negative.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 26, 1963
- Accession Number
- AD0424205
Entities
People
- James G. Crawford