HOST-PARASITE RELATIONSHIP IN MONKEYS ADMINSTERED LIVE TULAREMIA VACCINE VIA THE DERMAL OR RESPIRATORY ROUTE AND SUBSEQUENTLY CHALLENGED
Abstract
Investigation was made in vaccinated monkeys exposed via the respiratory route to 1000 cells of highly varulent Pasteurella tularensis SCHU S4 and serially sacrificed from one hour to 28 days thereafter. Earlier and more extensive dissemination as well as greater proliferation of the challenge strain occurred in nonvaccinated controls than in vaccinees. Focal accululation of monocytic cells in the pulmonary parenchyma was first observed in nonvaccinated controls, animals vaccinated dermally, and animalsnimals vaccinated aerogenically, on the first, third, and fifth day respectively, after challenge. In contrast to septicemia and fatal diesease in nonvaccinated controls within seven days after challenge, a reduction in number of SCHU S4 organisms occurred in the lungs, tracheobronchial lymph nodes, spleen, and liver of vaccinees between 14 and 28 days. Nonvaccinated controls and animals vaccinated dermally exhibited enlarged caseous tracheobronchial lymph nodes and moderate pulmonary involvement by the fifth day whereas animals vaccinated aerogenically did not show comparable pathology until seven to ten days after challenge.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1963
- Accession Number
- AD0424660
Entities
People
- Henry T. Eigelsbach
- Jerry J. Tulis
- Robert W. Kerpsack
Organizations
- United States Army Biological Warfare Laboratories