DEVELOPMENT OF BLOOD DIALYZER-ULTRAFILTRATOR.
Abstract
A small experimental model disc-cone dialyzer of 1,200 sq. cm. surface area has been completed and tested in vitro. The distribution of blood and dialyzing fluid is uniform. The apparatus is leak-proof and has excellent characteristics regarding ease of assembly, cleaning and use. An experimental model push-pull dialyzer has been designed which incooporates more than 10,000 sq. cm. of Cuprophan within a box of 3 1/2 in. x 3 1/2 in. x 6 in. The unit acts as its own blood pump. The direct compression, 3-chambered, ball-valved model has been found to be virtually non-hemolytic. It ;as been employed in 33 human dialyses and is felt to meet the most critical requirements for extracorporeal circulation of blood. A second model has been developed with slight modifications and at less manufacturing expense. The full scale clinical electrodialyzer previously described has been developed and tested in vitro and in vivo. Transport rates for salicylate, sulfate, phosphate, potassium and urea have been measured and compared to those obtained by passive dialysis in the same apparatus. Hemolysis remains a limiting factor and appears to be a function of current density and duration of electrodialysis. Heating of blood was also encountered. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 27, 1963
- Accession Number
- AD0424791
Entities
People
- Lewis W. Bluemle Jr.
Organizations
- University of Pennsylvania