THE MECHANISM OF ACTION OF ENDOTOXIN

Abstract

Evidence from this laboratory and others indicates that endotoxin shock is a form of anaphylactic shock mediated through natural antibody and characterized by complement-fixation in vivo; that resistance to endotoxin shock can be increased by the acquisition of further antibody; and that intestinal bacteria may influence susceptibility to endotoxin by their effect on the production of both natural and acquired antibody. The immunologic factors in the production of endotoxin shock were investigated further by the following studies: (1) A Systematic Analysis of the Reaction Between Endotoxin and Complement; (2) Immunization Against Bacteremic Shock by Feeding Viable E. coli; (3) The Influence of Immunilogic Paralysis Induced by Mitomycin C on Susceptibility to Endotoxin; and (4) A Comparison of the Toxic and Antigenic Properties of Endotoxin Purified by Density Gradient Zone Ultracentrifugation.

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Document Details

Document Type
Technical Report
Publication Date
Oct 31, 1963
Accession Number
AD0425884

Entities

People

  • Abraham I. Braude

Organizations

  • University of Pittsburgh

Tags

Communities of Interest

  • Advanced Electronics

DTIC Thesaurus Topics

  • Antibodies
  • Arthritis
  • Bacteria
  • Blood
  • Cells
  • Cellular Structures
  • Endotoxic Shock
  • Government Procurement
  • Immunologic Factors
  • Infection
  • Lethal Dosage
  • Lethality
  • Materials
  • Nitrogen Mustards
  • Resistance
  • Shock (Pathology)
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Combustion Dynamics and Shock Wave Physics.
  • Immunology
  • Microbial Pathology