EVALUATION OF RADIOPROTECTIVE AGENTS.
Abstract
A study is in progress to determine whether standard radioprotective agents (beta-mercaptoethylamine, p-aminopropiophenone, 2-aminoethylisothiouronium bromide, and serotonin) will protect mice against the late deleterious effect of X-ray exposure. A total of 7200 treated and control mice have been exposed to four dosage levels of X rays and set aside for longevity and histopathology studies. Both sexes from strains A/J and C57BL/6J have been included. Seven radioprotective agents provided by the Walter Reed Army Institute for Research have been evaluated in terms of chemical toxicity and radioprotective effect. The ratios of X-ray LD50 values for treated mice to the control LD50 values ranged from 1.2 to 1.6. The comparable values for the standard agents listed above were 1.5 and 1.8. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1963
- Accession Number
- AD0427279
Entities
People
- John B. Storer