CANINE VACCINATION WITH VIABLE COCCIDIOIDES IMMITIS; CONTROL OF TISSUE REACTION WITH ANTIBIOTIC THERAPY

Abstract

Evidence has been presented that the subcutaneous vaccination of dogs with viable Coccidioides immitis arthrospores offers good protection against subsequent respiratory challenge with a large dose of live arthrospores. The administration of oral presolubilized Amphotericin B (Fungizone) following vaccination eliminated the undersirable side effects of the vaccine but did not interfere with the development of immunity. No physiologic or histologic evidence of renal damage attributable to Amphotericin B was demonstrated.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1953
Accession Number
AD0427614

Entities

People

  • John L. Converse
  • Merida W. Castleberry
  • Peter J. Soto Jr.

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amphotericin
  • Blood
  • California
  • Cells
  • Diseases And Disorders
  • Fungi
  • Giant Cells
  • Immunity
  • Lymph Nodes
  • Lymphatic System
  • Lymphocytes
  • Mycoses
  • New York
  • Side Effects
  • Therapy
  • United States
  • Vaccination

Fields of Study

  • Medicine

Readers

  • Immunology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology