NEW METHODS DEVELOPMENT FOR IRRITANT SCREENING

Abstract

Peritoneal mast cells have been found to liberate too small a quantity of histamine to permit evaluation of the activity of irritants. Guinea pig lungs appear suitable. Mice and dogs appear inferior to rabbits for evaluation of eye irritation. Assessment by current methods has now been accomplished on a cumulative total of approximately 280 compounds.

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Document Details

Document Type
Technical Report
Publication Date
Jan 10, 1964
Accession Number
AD0429378

Entities

People

  • E. R. Hart

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Animals
  • Cells
  • Contractors
  • Contracts
  • Histamine
  • Irritants
  • Irritation
  • Lagomorphs
  • Mast Cells
  • Monkeys
  • Rhesus Monkeys
  • Rodents
  • Smooth Muscle
  • Test And Evaluation
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Regression Analysis.
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology