EFFECTS OF BICARBONATE ON GROWTH OF PASTEURELLA PESTIS. I. A DIFFERENTIAL RESPONSE OF VIRULENT AND AVIRULENT CELLS

Abstract

The observation of Delwiche et al that the virulence of broth cultures of Pasteurella pestis aerated at 37 C can be maintained by addition of bicarbonate was confirmed and extended. A differential growth response by virulent and avirulent cells to added bicarbonate under certain conditions was demonstrated. The effect of supplemental bicarbonate on initiation of growth from a virulent inoculum was found to be (a) stimulation of both virulent and avirulent cells at low levels of added bicarbonate, (b) depression of both virulent and avirulent cells at higher initial concentrations, or (c) depression of avirulent mutants with simultaneous stimulation of virulent cells at a narrow range of intermediate levels.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1964
Accession Number
AD0431827

Entities

People

  • A. W. Andrews
  • C. L. Baugh
  • M. J. Surgalla

Organizations

  • United States Army Biological Warfare Laboratories

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DTIC Thesaurus Topics

  • Aluminum Foil
  • Availability
  • Biological Laboratories
  • Biological Sciences
  • Biomedical Research
  • Carbon Dioxide
  • Cells
  • Confidence Limits
  • Gammaproteobacteria
  • Laboratory Animals
  • Magnesium
  • Materials
  • Production
  • Toxicity
  • United States
  • Virulence

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  • Analytical Chemistry
  • Microbial Pathology