INFECTIVITY AND ANTIGENICITY OF STREPTOMYCIN-DEPENDENT SALMONELLA TYPHOSA

Abstract

A streptomycin-dependent mutant of Salmonella typhosa injected live in rabbits stimulated the production of 0 antibodies. Sera from these rabbits protected mice against challenge with virulent S. typhosa. Mutation to the dependent state did not result in loss of antigenicity. Streptomycin dependency of the mutant was demonstrated in vivo in the mouse. Antibiotic treated mice succumbed to challenge with dependent bacilli, apparently because of presence of lethal quantities of endotoxin produced by multiplication of the mutant in the presence of streptomycin.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1964
Accession Number
AD0432431

Entities

People

  • Morton Reitman

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adsorption
  • Anti-Bacterial Agents
  • Antibodies
  • Bacterial Toxins
  • Biological Factors
  • Biological Laboratories
  • Biological Products
  • Diseases And Disorders
  • Endotoxins
  • Immune Serums
  • Immunomodulation
  • Infection
  • Medical Personnel
  • Production
  • Toxicity
  • Virulence
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Military/Explosive Ordnance Disposal (EOD) Technology
  • Virology (or Medical Virology).