IONIC RELATIONSHIPS OF THE BIOELECTROGENIC MECHANISM IN ISOLATED RAT STOMACH,
Abstract
The potential as measured in vitro across rat stomach was examined by substitution, inhibition and flux studies. The effect of choline substitution for sodium on the potential was shown to be immediate, and to act on the mucosal influx, changing it from 1.4 to 0.2 micro eg of sodium/hr. Anoxic condition affected mucosal outflux only. The transmembrane potential is linearly dependent on mucosal sodium concentration to 55 mMolar, where the system apparently becomes saturated. Replacement of chloride by sulfate raises the potential. A potassium requirement could be demonstrated by the elimination of chloride, and a calcium deficiency was noted only in the presence of high concentrations of EDTA. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 10, 1964
- Accession Number
- AD0433804
Entities
People
- B. E. Vaughan
- J. T. Cummins
Organizations
- Naval Radiological Defense Laboratory