Carcinogenesis by Fast Neutrons Relative to X Rays in Mice: Effect of Uninephrectomy and of CC14,
Abstract
This investigation is an attempt to provide further insights into the potential long-term carcinogenic hazards of radiation, and into the mechanisms of carcinogenesis. Young adult LAFl mice were exposed to a single high sublethal dose of fission spectrum neutrons. They were subjected to unilateral nephrectomy, carried out 1 day before neutron irradiation, or a single CC1 injection 1 day befor neutrons or 1 month after neutrons. These and the control groups were sacrificed 12 - 16 months postirradiation. The data show a striking enhancement of liver tumor incidence (75%) in the neutron-irradiated mice receiving CC1 one month after irradiation, and an even greater incidence (92%) when the CC1 was administered one day prior to irradiation. By contrast, liver tumors appeared in 14% of mice receiving neutron irradiation only and in 2.4% of mice exposed to a single dose (500 rad) of 200 kvp X rays. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 15, 1964
- Accession Number
- AD0433886
Entities
People
- Leonard J. Cole
- P. C. Nowell
Organizations
- Naval Radiological Defense Laboratory